Results
| PMID | 20339793 |
| Gene Name | TNF |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 98 |
| Population details | 98 (65 patients with endometriosis (Group A) and 33 without the disease (Group B)) |
| Sex | Female |
| Associated genes | IL 2, 4 and 10, TNF-alpha and IFN-gamma |
| Other associated phenotypes |
Endometriosis |
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Rev Assoc Med Bras (1992). 2010 Jan-Feb;56(1):92-8. Podgaec, Sergio| Dias Junior, Joao Antonio| Chapron, Charles| Oliveira, Ricardo Manoel de| Baracat, Edmund Chada| Abrao, Mauricio Simoes Departamento de Obstetricia e Ginecologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP. OBJECTIVE: This study analyzed the relationship between clinical characteristics of endometriosis and Th1/Th2 immune response patterns. METHODS: A prospective study was performed with 65 patients with endometriosis (Group A) and 33 without the disease (Group B). Measurement of IL 2, 4 and 10, TNF-alpha and IFN-gamma was carried out in peripheral blood and peritoneal fluid. RESULTS: Serum TNF-alpha was higher in patients with endometriosis who had deep dyspareunia compared to controls (mean 4.5 pg/ml and 2.3 pg/ml, p<0.05). Among these patients (n=32), 65.5% had deep endometriosis. Patients with endometriosis and infertility had higher IL-2 concentrations in peritoneal fluid than controls (mean 5.9 pg/ml and 0.2 pg/ml, p<0.05). Among these patients (n=22), 63.5% (n=14) had deep endometriosis. A higher concentration of IL-10 was also observed in patients with ovarian endometriosis when compared to those without this type of disease, as well as when compared to control group patients (mean 50 pg/ml, 18.7 pg/ml and 25.7 pg/ml, p<0.05). CONCLUSIONS: These results suggest that when specific clinical data are associated with a higher production of certain cytokines, there is a Th1 response pattern that may be related to deep infiltrating endometriosis. Mesh Terms: Adult| Ascitic Fluid/chemistry/immunology| Case-Control Studies| Cytokines/*analysis/immunology| Endometriosis/*immunology| Female| Humans| Prospective Studies| Th1 Cells/*immunology| Th2 Cells/*immunology|DA 2011/10/01 06:00 |
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